Can you replace r22 refrigerant with r410a?

R22 and R410A are incompatible. The new higher pressure refrigerant is not compatible with your existing unit. ... You can either rebuild the enclosure or buy a new air handler that provides more air for the new coil.The R22 refrigerant and its replacement of the HFC R410A are totally incompatible. Its condensing units and refrigerant coil are not suitable for the new high pressure refrigerant. This cabinet will have to be rebuilt, or if it is necessary to buy a new air control that provides a higher air flow required by the new refrigerant.